Human methylenetetrahydrofolate reductase plus SAM
Blomgren LKM, Huber M, Mackinnon SR, Burer C, Basle A, Yue WW, Froese DS, McCorvie TJ
To Be Published
Image sets:
Resolution: 3.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8s5h
Q-score: 0.408
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8s5i
Q-score: 0.396
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
Full-length human cystathionine beta-synthase, basal state, helical reconstruction
Resolution: 3.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 8s5j
Q-score: 0.434
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
Full-length human cystathionine beta-synthase, basal state, single particle reconstruction
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8s5k
Q-score: 0.341
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
Full-length human cystathionine beta-synthase, basal state, partially degraded tetramer
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8s5l
Q-score: 0.454
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Cystathionine beta-synthase (60 kDa, Protein from Homo sapiens)
- Cystathionine beta-synthase (60 kDa, Protein from Homo sapiens)
- Helical assembly of full-length human cystathionine beta-synthase in the basal state (Complex from Homo sapiens)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
Resolution: 4.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8s5m
Q-score: 0.222
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
MTHFR + SAH symmetric dis-inhibited state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8qa4
Q-score: 0.536
Blomgren LKM, Huber M, Mackinnon SR, Burer C, Basle A, Yue WW, Froese DS, McCorvie TJ
Nat Commun (2024) 15 pp. 3248-3248 [ DOI: doi:10.1038/s41467-024-47174-y Pubmed: 38622112 ]
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Methylenetetrahydrofolate reductase (nadph) (75 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Human 5,10-methylenetetrahydrofolate reductase in complex with s-adenosyl-l-homocysteine, regulatory domains (150 kDa, Complex from Homo sapiens)